CR-2 Plus AF

Canon was the very first company to introduce a Non-Mydriatic Retinal Camera as far back as 1976. 

Built on this legacy, the CR-2 Plus AF is equipped with superb Canon optics and Canon’s own EOS digital camera technology. This technology includes Canon’s renowned image processing capabilities which have been adapted exclusively for its retinal cameras in order to offer optimal retinal imaging for the highest image quality.

In addition, Canon's unique Opacity Suppression largely suppresses the effects of cataracts and other ocular opacities.

In addition to the photometric Auto Exposure, the CR-2 Plus AF offers low flash photography. This feature greatly reduces the patients’ discomfort. Workflow is also improved as images of both eyes can be captured without being restricted by the pupils’ size. This is ideal for photophobic patients.

The CR-2 Plus AF offers the possibility to pre-set four fixation lamps patterns for internal fixation. Each pattern has a maximum of nine positions. This is an excellent feature when various screening protocols are used.

CR-2 Plus AF provides Non-Mydriatic images at a 45 degrees angle (67.5 degrees when using center of eye ball as reference).

Fundus Autofluorescence (FAF) is a diagnostic technique for documenting the deposition of lipofuscin in the retinal pigment epithelium (RPE). As an easy and non invasive technique, it provides information that may otherwise not be clinically detectable. It can be a valuable asset in diagnosing retinal disease.

Since the introduction of fluorescein angiography (FFA) in 1959, ophthalmologists observed that even without the use of fluorescein, parts of the fundus would show areas of faint fluorescence under certain conditions. This naturally occurring fluorescence is mainly caused by Lipofuscin, a fluorescent pigment that accumulates in the RPE as a metabolic byproduct of cell function.

Lipofuscin deposition normally increases with age, but may also occur from RPE cell dysfunction or an abnormal metabolic load on the RPE. FAF imaging can visualize the deposition of lipofuscin in the retinal pigment epithelium (RPE). Areas of excess Lipofuscin accumulation will appear hyperfluorescent. However, when RPE cells die or are absent, LF disappears, leading to hypofluorescence.

In this example, it is clear that the FAF image is showing additional clinical information that can’t be seen in the colour image!

The Canon CR-2 Plus AF utilizes green light spectrum to stimulate the retina and capture the emission in the yellow-orange spectrum while utilizing carefully selected matching optical filters. The green spectrum may provide more detail in the fovea, where as blue light tends to be absorbed by the high concentration of macular pigments. An additional advantage of green light is that the longer wavelength tends to have less absorption by the crystalline lens of the eye, especially in patients with cataracts.

Normal distribution of lipofuscin

Retinal pigment epithelial atrophy

Without having the requirement to take an additional image, the RX software can create a digital red-free or cobalt image from a colour image. This is based on Canon’s EOS retina technology and its proprietary image processing that uses the digital camera’s original RAW image. 

The image quality is fully comparable with those obtained via optical filters.